Inside the cell, an ocean of buffeting waves

first_imgConventional wisdom holds that the cytoplasm of mammalian cells is a viscous fluid, with organelles and proteins suspended within it, jiggling against one another and drifting at random. However, a new biophysical study led by researchers at Harvard University challenges this model and reveals that those drifting objects are subject to a very different type of environment.The cytoplasm is actually an elastic gel, it turns out, so it puts up some resistance to simple diffusion. But energetic processes elsewhere in the cell — in the cytoskeleton, especially — create random but powerful waves in the cytoplasm, pushing on proteins and organelles alike. Like flotsam and jetsam buffeted by the wakes of passing ships, suspended particles scatter much more quickly and widely than they would in a calm sea.Because transport within the cytoplasm therefore depends mainly on separate processes that consume energy, a measurement of the spectrum of forces exerted on the cytoplasm at any given time can provide a snapshot of the metabolic state of the cell.Led by David A. Weitz, Mallinckrodt Professor of Physics and Applied Physics at the Harvard School of Engineering and Applied Sciences (SEAS), a team of applied physicists and cell biologists have put forth this new model of the cytoplasm and demonstrated a way to quantify the aggregate forces felt by particles and organelles in the cell. Their findings, published online August 14 in the journal Cell, raise a host of new questions about cellular dynamics. They also provide a robust new tool for future investigations. Read Full Storylast_img read more

Harpole notches North Dakota first with IMCA Stock Car rookie of the year prizes

first_imgEric Harpole earned national and EQ Cylinder Heads Northern Region IMCA Sunoco Stock Car rookie of the year honors this season. He is pictured with IMCA President Brett Root. (Photo by Bruce Badgley, Motorsports Photography)BISMARCK, N.D. – After putting on some miles during the final weekend of the point season, Eric Harpole could make plans on where to display IMCA Sunoco Stock Car national and EQ Cylinder Heads Northern Region rookie of the year awards.From Bismarck, Harpole became the first North Dakota driver to win either award, by a scant one point margin over Tommy Fose. He ran both nights at Beatrice Speedway’s Septemberfest, then loaded up the next morning to head for Quincy Raceway in Illinois.“I left Beatrice at 10 a.m. on Sunday and pulled into Quincy with just enough time to zip tie the car together,” he said. “We went out, hoped for the best and finished fourth.”Harpole had raced a Wissota street stock, which he said was similar to an IMCA Sunoco Hobby Stock, for five years. Buddies Bob Fuegmann and Mike Swallers already raced in the Stock Car division and encouraged him to do so as well.“I wanted something more. The Stock Car is more of a race car. You can’t adjust a street stock the way you can a Stock Car,” Harpole explained. “It’s a fun class. After racing a Stock Car, I’m happy I made the switch.”His weekly point season travels took Harpole to 10 tracks in four states; he also qualified for four of the Kupper Chevrolet Dakota Classic Tour main events.Harpole got his first of three wins in just his third night out, at McLean County Speedway.“I did not think my first win would come that quickly,” he said. “The national rookie award was a pipe dream at the start of the season but as the year went on and things came into scope, I thought why not run for it?”Starts-42Wins-3Additional Top Fives-17HIS CREW: Father Terry, mother and stepfather Laura and Corey Wamsley, brother Landon, girlfriend Meaghan Hoff, Ryan Novak, Terry Faul and Russ John. HIS SPONSORS: Benz Ranch and Zimmerman Manufacturing, both of Steele; Elite Ag Solutions and Harpole Trucking, both of Dawson; Auto Express Towing of Bismarck; Big Tex Trailers/The Trailer Store of Mandan; and Falkenstein Farms of Wilton.last_img read more

Players get more choice, colleges could be squeezed by reshaped G League program

first_img How athletes protesting the national anthem has evolved over 17 years The G League attempted to push back against this trend starting in 2018, but no one took them up on the offer before Green last week. The original program would have paid prospects $125,000 to enter the G League draft with the rest of the talent pool, meaning players could possibly play in the league’s far-flung markets in South Dakota or Maine. That isn’t exactly appealing compared to the ability to choose one’s college market and appear on ESPN with Duke or Kentucky.The original structure also created a problem for G League teams, who faced the possibility of coaching a player for one year that they wouldn’t retain NBA rights for. Typically there’s a hierarchy for the importance of G League players: those on the 15-man roster, then two-way contract players, then the rank-and-file of the G League. Promising 18-year-olds who signed with the G League risked getting shuffled on that lowest tier, South Bay Lakers coach Coby Karl said. There’s no added incentive to develop a player you can’t keep.“A guy could be a projected lottery pick, but if he’s not better than (a player on the NBA roster), it’s not my responsibility to play him,” Karl said of the previously proposed structure. “A kid could be our most athletic player, but what would determine playing time is if he helps our team win games.”Former California player and current NBA G League President Shareef Abdur-Rahim talks to reporters before an NCAA college basketball game between California and Colorado, Thursday, Feb. 27, 2020 in Berkeley, Calif. (AP Photo/D. Ross Cameron)When Abdur-Rahim assumed leadership last year, reshaping the select program became one of his directives — and with a four-star son Jabri, he was able to see it through a parent’s eyes. Players and parents wanted a developmental environment, not one where prospects would be simply tossed into the fire of a physical league of men who can range into their mid-30s.Along with Rod Strickland, who did the lion’s share of the recruiting and leg work to sign the prospects, Abdur-Rahim tried to make the Select Team more of its own atmosphere — giving the players a chance to compete at the G League level, but offering a smoothed-out ramp between the prep level and the NBA.The league’s official stance is that many details, including the program’s location and the personnel involved, are still being hammered out. But several outlets have reported that former NBA coach Sam Mitchell will front the program, with other former NBA coaches (former Lakers assistant Brian Shaw is rumored to be involved) helping out. Several outlets have reported that the Mamba Sports Academy in Thousand Oaks is one of the locations under consideration.While Nix will never wear the blue and gold of the Bruins, he might well get a chance to compete in front of Southern California hoops fans on his new path.“I think that’s a great market, if it turns out that’s where they’re playing,” Lockridge said. “That would be ideal as a home base, with the environment, the climate, the city itself, all the buzz that comes through — it would be fantastic.”It would also be fantastic for NBA talent evaluators, who could easily catch glimpses of potential lottery picks stateside against G League players. Competitive environments are where scouts and coaches learn the most, and G League coaches like Karl could find ways to push the buttons of prospects to see how they respond in exhibitions.“That’s the essence of when you get to know someone: How do they act when they’re up, or when they frustrated?” Karl said. “We’ll be able to put our best defender on him to trap him and see how he reacts, or get physical and put his butt down and see how he responds.”While the more immediate threat to the NBA this past year was the stream of prospects headed overseas, the increased appeal of the Select Team poses an existential threat to college basketball. NBA officials frequently cite the findings of a college basketball commission headed by Condoleezza Rice in 2018, which found that “one-and-done” prospects in college basketball have corrupted and destabilized the game. But stars such as Kevin Durant, Anthony Davis and Zion Williamson have also undoubtedly elevated the competition and increased interest and viewership.Abdur-Rahim said the idea isn’t for the G League to compete with the NCAA for prospects and interest, but to offer another path for the players who are likely good enough to play in the league and aren’t interested in the college experience.“College basketball will go forward and continue to be great,” he said. “We think it’s fair for players to have an alternative.”Related Articles Trail Blazers beat Grizzlies in play-in, earn first-round series with the Lakers Newsroom GuidelinesNews TipsContact UsReport an Error Clippers rookies key overtime victory over Oklahoma City Lakers practice early hoping to answer all questions center_img Before he moved to the desert — before he would become one of the top young point guard prospects in America — Daishen Nix tried to steal all the hours of daylight he could.In the summers in Anchorage, Alaska, the sun can linger in the sky for more than 19 hours. It was common for Nix, then a middle-school-aged boy, to spend those long sunsets on an outdoor court until midnight, when his mother would come to fetch him.The willingness to put in the hours has never been his issue, his coach and legal guardian Greg Lockridge said. So years later, when the NBA offered Nix, a 6-foot-5 five-star McDonald’s All-American who could be a first-round pick in the 2021 NBA Draft, an opportunity to spend a year in a revised G League select program, it made a lot of sense for Nix and his family to combine his work ethic with pro expertise.“It wouldn’t matter if he was by himself or with a crowd, this kid has a passion that is just bar none,” Lockridge said. “We thought it would give him a huge advantage going into the draft —  his upside is tremendous.” From a market standpoint, it helps prospects like Nix, who can start cashing in on his potential now rather than wait a year. But it could be a more grim future for coaches like Mick Cronin, who personally recruited Nix over the last year according to Lockridge. Both Lockridge and Nix believed in Cronin’s ability to develop his talent, and felt validated as he helped lead the Bruins’ midseason turnaround this past year before the season was suspended due to COVID-19.Nix had heard from the G League as far back as last fall, but only started seriously considering it recently. Withdrawing his commitment from the Bruins was a careful decision.“I can’t really say how a man feels in his heart, but I know (Cronin) was very professional in his response, wishing Daishen the best of luck,” Lockridge said. “He has to go on, but he’s a heck of a coach and he’s got some pieces that can help him.”It’s just a smaller pile of pieces to pick from. AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREUCLA alum Kenny Clark signs four-year contract extension with PackersThat’s the pitch the NBA G League is now giving to families of top prep recruits: While the prep-to-NBA days have been on hold since 2006, the NBA’s developmental league is now selling top recruits into a yearlong development program in which they would compete in exhibitions against G League teams and possibly national youth teams from other countries.It’s a pitch sweetened by contracts reported to be worth hundreds of thousands of dollars: The Athletic reported Nix, who announced his intentions on Tuesday, is expected to make “in the $300,000 range.” Nix had been committed to UCLA, where he would have earned a scholarship and stipend worth considerably less, especially if he had only stayed one year.But the money is just part of the picture, said Shareef Abdur-Rahim, a former NBA star who now serves as the G League’s commissioner and has oversees the pathway program. But if it was just money, players like Nix, Jalen Green and Isaiah Todd — consensus top 20 recruits who have all signed with the G League — could make comparable salaries in overseas markets like China or Australia.“It’s the aggregate of what we’re putting together, and kids wanting to be part of that,” Abdur-Rahim said. “What this program does is it targets your development for the NBA in a way that prepares you for the NBA.”Daishen Nix, a top-rated point guard from Trinity International School in Las Vegas, signed to play at UCLA but subsequently chose the G League. (Photo courtesy of USA Basketball)The G League select team is the NBA’s answer to an age when high-level recruits are increasingly conscious of the dollar value they command. The NCAA has long been the developmental pipeline of players to the league, but it’s become more common than ever for a handful of the nation’s elite to consider an overseas professional year, or simply take a gap year to train privately. In the upcoming draft class, high-level recruits LaMelo Ball and R.J. Hampton both spent the last season in the Australian league — frustrating would-be scouts who have to take international flights to see American players up close. Clippers’ rhythm is missing but their spirits strong before playoff opener last_img read more

Crystal Palace are the third best team in England since Feb 2019 according to…

first_imgAdvertisement 3estx6NBA Finals | Brooklyn Vsi2uWingsuit rodeo📽Sindre Eet8( IG: @_aubreyfisher @imraino ) jjWould you ever consider trying this?😱lfpCan your students do this? 🌚5ooiRoller skating! Powered by Firework Crystal Palace are showing great form under the management of Roy Hodgson. According to the statistics they are the third best team of England after Manchester City and Liverpool. Since the victory against Fulham on 2nd February, Crystal Palace have collected 30 points from their 17 matches.Advertisement Chelsea and Arsenal have collected one point less than Crystal Palace in the meantime. Tottenham Hotspur and Manchester United are also way behind them in the points table in this span of time period. Recently Crystal Palace have beaten Manchester United at Old Trafford with a margin of 2-1.Advertisement After that result, the talks have been started about Crystal Palace. Crystal Palace are one of the most consistent sides in English Premier League to perform well in recent times. Crystal Palace were one of the best sides in England under the management of Roy Hodgson. The players like Wilfried Zaha, Patrick Van Aanholt, Townsend, Ayew have certainly been important for Crystal Palace in achieving this feat. Crystal Palace’s unique style of play is helping them to get good results against the top six sides too.Roy Hodgson is certainly doing a great job at Crystal Palace and his aim will be finishing at the top  half of the table by the end of this season.Advertisement Tottenham edge past Juventus with a last minute winner of Harry Kane Advertisementlast_img read more